Poplar Bluff, MO is a city located in Butler County, Missouri and has a land area of 285.01 square miles (738.17 km2). The water area for the city is 1.30 square miles or 3.37 km2. There are 2 total unique zip codes in Poplar Bluff, Missouri. The area code(s) for Poplar Bluff is 573.
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